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Prevalence of chronic kidney disease in an admixed population of patients with type 1 diabetes. A multicenter study in Brazil

Diabetes Research and Clinical Practice Oct 07, 2020

Gomes MB, Pizarro MH, Muniz LH, et al. - Researchers conducted this cross-sectional, multicenter study to assess diagnosis, prevalence and associated factors of chronic kidney disease (CKD) in Brazilian patients with type 1 diabetes. This investigation was carried out in 14 public clinics in 10 Brazilian cities. From 1,760 patients, 1,736 were involved (98.6%): 977 females (56.3%), 932 (54%) Caucasians, aged 29.9 ± 11.9 years, age at diagnosis 14.7 ± 8.9 years, diabetes duration 15.5 ± 9.3 years and 12.2 ± 3.8 years of school attendance. Data reported that CKD prevalence was 33.7%. According to multivariable analysis, female gender, duration of diabetes, high HbA1c and uric acid levels, use of renin-angiotensin system inhibitors, retinopathy, high systolic BP, and economic status (medium, low and very low) were linked to CKD. Although the study observed a high prevalence of CKD, related comorbidities and retinopathy, a large number of patients are still undiagnosed, rendering CKD in admixed populations with T1D in a developing country such as Brazil a challenge in clinical practice.

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