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Prevalence of cardiovascular disease risk factors in childhood glomerular diseases

Journal of the American Heart Association Jul 13, 2019

Ashoor IF, et al. - Researchers examined children (n=761) 0 to 17 years old with any of four biopsy-confirmed primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy/vasculitis) to investigate the prevalence of cardiovascular risk factors (hypertension, hypercholesterolemia, obesity, proteinuria, prematurity, and passive smoke exposure) in these patients, as well as to report contemporary practice patterns concerning detecting and managing risk factors. Participants were enrolled in the multicenter prospective Cure Glomerulonephropathy Network study at a median of 16 months from glomerular disease diagnosis. All traditional risk factors were more frequently seen in these children vs the general population; among those screened, 21% had hypertension, 51% were overweight or obese, and 71% had dyslipidemia. Hypertension and hypercholesterolemia were more common in children who were not in remission at enrollment. Only 49% were screened for dyslipidemia; only 9% of those with confirmed dyslipidemia were given lipid-lowering medications. The reported frequency of modifiable cardiovascular risk factors in children with primary glomerular diseases was high, and this was especially true for untreated dyslipidemia. In this population, routine assessment of lipid panels is recommended to better define the burden of dyslipidemia.

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