Jack Jr CR, Therneau TM, Weigand SD, et al. - In this population-based cohort study among a sample of 5,213 people from Olmsted County, Minnesota, researchers determined the gender- and age-specific prevalence of three imaging biomarker-based definitions of the Alzheimer disease spectrum from the National Institute on Aging–Alzheimer Association research framework and contrasted these entities with clinically defined diagnostic entities usually associated with Alzheimer disease. Compared with clinically defined probable Alzheimer disease for women and men, the predominance of biological Alzheimer disease was greater. The only significant variation by gender was a greater predominance of the mild cognitive impairment or dementia clinical category among men vs women. Hence, outcomes of this study imply that biologically defined Alzheimer disease is more common in compared with clinically defined probable Alzheimer disease at any age and is three times more common at age 85 years among both women and men. This variation is often motivated by asymptomatic people with biological Alzheimer disease. These findings demonstrate the extent of the consequences of public health that possibly exist via interrupting with disease-specific treatments to limit symptom onset.