Nyemba DC, Medina-Marino A, Peters RPH, et al. - Via combining data from two prospective observational studies enrolling pregnant women while they were attending their first antenatal clinic (ANC) visit in Tshwane District and Cape Town, researchers sought to determine the prevalence and incidence of STIs in pregnant women and the correlated risk factors. Among 669 enrolled pregnant women, [64% (n = 427) from Tshwane District and 36% (n = 242) from Cape Town], 80% (n = 534) were women living with HIV (WLHIV) and 20% (n = 135) without HIV. At enrolment, diagnosis of at least one STI was made in 37% (n = 250), of which 76% (n = 190) were asymptomatic. Overall findings suggest a high prevalence and incidence of STIs in pregnancy, especially in WLHIV. This emphasizes the necessity for STI screening in ANC to avert adverse pregnancy and birth outcomes. Most STI cases were noted to be asymptomatic and would remain untreated with syndromic management. They suggest an urgent necessity for aetiological STI screening to decrease the burden of STIs in pregnancy.