Hosseini K, Mortazavi SH, Sadeghian S, et al. - In this analysis of patients with obstructive (> 50% stenosis) coronary artery disease (CAD), following were the main findings and were expected: a lower age of CAD diagnosis in men, lower age of diagnosis associated with most risk factors, and lower prevalence of serum lipids over time. Evidence corroborates an association of opium use with a much younger age of CAD onset, even post-adjusting for all other risk factors.

• This is a registry-based, serial cross-sectional study to assess prevalence and 11-year trends of traditional CAD risk factors by gender and age, as well as their adjusted impacts on the age of CAD diagnosis.

• The coronary angiography data bank of the Tehran Heart Center was used to obtain data for 90,094 patients.

• A younger at diagnosis was evident in men vs women, and men had fewer risk factors at the time of diagnosis.

• An increasing trend was observed in body-mass index, hypertension prevalence, diabetes mellitus.

• Over time, reduction in all lipid profile components (total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol) was evident.

• Opium use was related to 2.2 year earlier age of CAD diagnosis.