Liu CN, Yu FB, Xu YZ, et al. - In this retrospective case-control study, researchers sought to determine the prevalence and risk factors for severe postpartum hemorrhage (SPPH), defined as an estimated blood loss ≥ 1,000 mL and total blood transfusion ≥ 4 units, among a cohort of women who gave birth after 28 weeks of gestation between January 2015 and August 2019. SPPH was found in 532 mothers (1.56%) of a total population of 34,178 mothers. Maternal age < 18 years, previous cesarean section, history of postpartum hemorrhage (PPH), conception through in vitro fertilization, pre-delivery anemia, stillbirth, prolonged labor, placenta previa, placental abruption, placenta accrete spectrum, and macrosomia were all risk factors for SPPH. Extra vigilance is required during the antenatal and peripartum periods to identify women with risk factors and enable early intervention to prevent SPPH.