Mogire RM, Morovat A, Muriuki JM, et al. - Researchers sought to determine the prevalence as well as predictors of vitamin D deficiency among young African children. This study included 4,509 children aged 0–8 years living in Kenya, Uganda, Burkina Faso, The Gambia and South Africa. In participants, experts recorded 25-hydroxyvitamin D (25(OH)D) and typed the single nucleotide polymorphisms, rs4588 and rs7041, in the GC gene encoding the vitamin D binding protein. The overall median 25(OH)D concentration was 77.6 nmol/L. Lower 25(OH)D levels were detected in South Africa, in older children, during winter or the long rains, and in those with afebrile malaria, while higher levels were seen in children with inflammation. Lower median 25(OH)D levels were found in participants carrying the Gc2 variant vs those carrying the Gc1f or Gc1s variants. About 0.6% and 7.8% of young African children were identified to have vitamin D deficiency as defined by 25(OH)D concentrations < 30 nmol/L and < 50 nmol/L, respectively. Considering certain factors such as latitude, age, season, and prevalence of inflammation and malaria, in strategies to evaluate as well as manage vitamin D deficiency in young children living in Africa, is recommended.