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Prevalence and course of disease after lung resection in primary ciliary dyskinesia: A cohort & nested case-control study

Respiratory Research Oct 19, 2019

Kouis P, Goutaki M, Halbeisen FS, et al. - Researchers evaluated the prevalence of lung resection in Primary Ciliary Dyskinesia (PCD) across countries, and performed comparison between lobectomised and non-lobectomised patients with respect to disease course. They selected lobectomised and non-lobectomised age and gender-matched PCD patients from the international PCD cohort (iPCD) and carried out cross-sectional and longitudinal comparisons of their characteristics, lung function and BMI. The iPCD cohort included 2,896 patients, of these, lung resection was received by 163 from 20 centers (15 countries). A wide variation was noted in the prevalence of lung resection in PCD across countries. Commonly, lung resection in PCD was performed prior to the diagnosis of PCD and overall was more common in patients with delayed diagnosis. Following lung resection, poorer and continuing reduction of lung function despite lung resection was observed in most of the lobectomised patients vs controls.
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