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Prevalence and clinical aspects of mild cognitive impairment in Parkinson disease: A meta-analysis

Movement Disorders Nov 28, 2019

Baiano C, et al. - In order to offer a robust estimate of the prevalence rate of mild cognitive impairment in Parkinson disease (PD) as per the Movement Disorder Society clinical criteria, as well as to determine the disparities in demographic, clinical, and neuropsychiatric characteristics between PD patients with and without mild cognitive impairment, researchers performed this meta-analysis. PsycInfo (PROQUEST), PubMed, and Scopus were used to carry a systematic literature search up to April 2019. They picked 41 studies, with 7,053 patients, out of 4,706 titles and abstracts. Among 7,053 PD patients, the pooled mild cognitive impairment prevalence was found to be 40% with a higher frequency for the multiple domain subtype. In meta-regression analysis, they found that the prevalence estimates of mild cognitive impairment were moderated by stage of PD. In PD, the link of mild cognitive impairment with factors such as older age, lower education, longer disease duration, higher levodopa equivalent daily dose, more severe motor symptoms, and postural instability/gait difficulty motor subtype, poorer quality of life, higher levels of apathy, and depression, was found. Overall, in PD, mild cognitive impairment represents a common cognitive status that is worthy of early detection via standardized cognitive evaluations in clinical practice.
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