Sanchis IM, Shukoor S, Irazabal MV, et al. - Since the most one of the worst complications of autosomal dominant polycystic kidney disease is intracranial aneurysm rupture, researchers assessed presymptomatic screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease to determine whether selective or widespread intracranial aneurysm screening is indicated in these patients. They reviewed the records of 3,010 patients, including those who had presymptomatic magnetic resonance angiography screening. Presymptomatic screening enabled the detection of intracranial aneurysms in 9% of the overall patients studied—more commonly in those with familial history of subarachnoid hemorrhage, hypertension, or smoking. Aneurysmal ruptures occurred in none of the patients with, and two of the patients without, aneurysm detection on screening. Compared with the general population, this patient cohort had about five times higher overall rupture rates.