Tempfer C, et al. - Researchers investigated if intraperitoneal chemotherapy could be an alternative to systemic chemotherapy and cytoreductive surgery for patients with peritoneal carcinomatosis (PC). Via performing a systematic review of clinical and experimental evidence on the safety and efficacy of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with PC, they recognized PIPAC as feasible, safe, and effective. In patients with recurrent cancer and PC, PIPAC maintains quality of life. In women with ovarian cancer and PC, PIPAC is as evidence-based as any other treatment beyond the third line of systemic chemotherapy and can be recommended in this indication.