Ferry AV, Anand A, Strachan FE, et al. - Researchers determined how sex-specific criteria suggested for diagnosing myocardial infarction (MI) can influence presenting characteristics. In a sub-study of a prospective trial, patient-reported symptoms were assessed in 1,941 patients (39% women) with suspected acute coronary syndrome visiting the emergency department. Based on pain nature, location, radiation, and additional symptoms, typical and atypical presentations were defined by standardized criteria. The investigators used a high-sensitivity cardiac troponin I assay with sex-specific thresholds (> 16 ng/L women; > 34 ng/L men) to adjudicate the diagnosis of MI. Using this approach, they reclassified patients identified who were missed by the contemporary assay with a uniform threshold (≥ 50 ng/L). Women with MI, compared with men, more commonly had typical symptoms. A greater predictive value of typical symptoms was seen in women vs men with MI—irrespective of whether they received diagnoses using sex-specific criteria.