Schepis TS, et al. - Researchers examined differences in the health-related quality of life, mental and physical health, and substance use profiles by prescription opioid misuse (POM) history in US older adults (50 years and older). From the 2012–2013 National Epidemiologic Survey of Alcohol and Related Conditions-III, data of 14,667 adults 50 years and older were obtained. They grouped respondents into following mutually exclusive categories: no lifetime POM, prior-to-past-year POM, past-year POM, and persistent POM (ie, prior-to-past-year and past-year POM). They identified the greatest impairment, including lower mental and physical health–related quality of life and high rates of past-year major depression (17.6%), emergency department use (42.7%), and any substance use disorder (37.4%) among older adults with persistent POM. High rates of physical health diagnoses and healthcare utilization (eg, 45.6% past-year overnight hospitalization) were reported in older adults with past-year POM, while significant current psychopathology was reported in those with prior-to-past-year POM (eg, 13.7% with past-year major depression). These findings suggest a possible requirement of multidisciplinary care in older adults with persistent POM for their significant physical and mental health and substance use conditions.