Tubbs AS, Fernandez FX, Ghani SB, et al. - This study was carried out to investigate the relationships between a number of prescription insomnia medications and suicidal thoughts and behaviors. Researchers obtained data from the National Survey on Drug Use and Health for 2015 to 2018 and the National Health and Nutrition Examination Survey for 2005 to 2018. Binomial logistic regression was applied to calculate relationships of Z-drugs, trazodone, and sedative benzodiazepines (temazepam, triazolam, flurazepam) with suicidal ideation, planning, and attempts. Even after adjusting for measures of mental health, multiple classes of prescription insomnia medications are correlated with suicidal thinking and behaviors. After adjusting for age, sex, race/ethnicity, income, depression, illicit substance use, and K6 and WHODAS scores, Z-drugs were associated with suicidal ideation (OR 1.32), suicide planning (OR 1.44), and suicide attempts (OR 1.45), while sedative benzodiazepines were associated with suicide attempts (OR 1.76), but not suicidal ideation (OR 1.37) or suicide planning (OR 1.39). After adjusting for age, sex, race/ethnicity, and exposure to various psychotropic medications, in the NHANES, Z-drugs were linked with suicidal ideation (OR 2.44), as was trazodone(OR 2.33).