Bell KL, et al. - Authors tested the presumtion that utilization of opioids preoperatively would increase the incidence of subsequent periprosthetic joint infection (PJI) in patients undergoing primary total joint arthroplasty (TJA). They reviewed the patient records to extract relevant information, in particular details of opioid consumption, and an internal institutional database of PJI was cross-referenced against the cohort to identify patients who developed a PJI within 2 years of index arthroplasty. Findings suggested an independent association of preoperative opioid consumption with a higher risk of developing a PJI following primary total joint arthroplasty. Caution was suggested while prescribing opioids in patients with the degenerative joint disease who could later require arthroplasty.