López-Vicente M, et al. - In this investigation, researchers ascertained if higher omega-6:omega-3 (n-6:n-3) long-chain polyunsaturated fatty acid ratio in cord plasma was correlated with more attention deficit and hyperactivity disorder (ADHD) symptoms at 4 and 7 years of age. This research was based on a population-based birth cohort in Spain. In cord plasma, n-6 arachidonic acid and n-3 eicosapentaenoic and docosahexaenoic acid concentrations were measured. The data presented in this work showed a higher omega-6:omega-3 long-chain polyunsaturated fatty acid ratio in cord plasma was linked to a higher ADHD index at the age of 7. At the age of 4, the association was not observed. Using ADHD symptom diagnostic criteria, no associations were found. Overall, the investigators observed that high prenatal omega-6:omega-3 long-chain polyunsaturated fatty acid ratio preceded the appearance in mid-childhood of subclinical ADHD symptoms. The risk of developing long-term ADHD symptoms in offspring may be modulated by maternal diet during pregnancy.