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Prenatal exposure to cadmium and child growth, obesity and cardiometabolic traits

American Journal of Epidemiology Sep 28, 2018

Chatzi L, et al. - In 515 mother-child pairs in the “Rhea” cohort (Heraklion-Greece, 2007–2012), experts assessed the effect of prenatal cadmium exposure on child growth, adiposity, and cardiometabolic traits. Urinary cadmium concentrations during early pregnancy were measured and associations with repeated weight and height measurements were evaluated from birth through childhood; at 4-years, associations with waist circumference, skinfold thicknesses, blood pressure, serum levels of lipids, leptin, and C-reactive protein were evaluated. Findings suggested an association of the prenatal cadmium exposure with delayed growth in early childhood. They noted a significant correlation of elevated prenatal cadmium levels with slower weight trajectory in all children, and slower height trajectory in girls and in children born to mothers who smoked during pregnancy.

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