DeBolt CA, Bianco A, Limaye MA, et al. - Via this multicenter, retrospective, case-control study, the outcomes of severe and critical cases of coronavirus disease 2019 in pregnant vs nonpregnant, reproductive-aged women are described. From 4 academic medical centers in New York City and 1 in Philadelphia, they assessed 38 pregnant women who were admitted with severe acute respiratory syndrome coronavirus 2 polymerase chain reaction-confirmed infections; of these, 29 (76.3%) met the criteria for severe disease status and 9 (23.7%) met the criteria for critical disease status. Reproductive-aged, nonpregnant women admitted for severe or critical coronavirus disease 2019 were included as the controls. Findings revealed an increased risk for certain morbidities among pregnant women with severe and critical coronavirus disease 2019 vs nonpregnant controls. Although the nonpregnant controls had higher comorbidities of diabetes and hypertension, the pregnant cases were noted to be at raised risk for composite morbidity, intubation, mechanical ventilation, and intensive care unit admission. Findings overall suggest a correlation of pregnancy with a worse outcome in women with severe and critical cases of coronavirus disease 2019. Pregnant women may be at greater risk for morbidity and disease severity similar to other viral infections such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus.