Cauldwell M, Mackie FL, Steer PJ, et al. - Researchers examined a cohort of women with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) for maternal, obstetric, and neonatal outcomes. They performed a retrospective cohort study including women with a diagnosis of PBC and PSC and a pregnancy of ≥ 20 completed weeks of gestation at 10 specialist centers managing pregnant women with liver disease. Assessment of the first recorded pregnancies of 34 women with PSC and 27 women with PBC was performed. Sixty live births and one intrapartum stillbirth that did not occur in the context of maternal cholestasis were reported. Observations suggest that pregnancy is well tolerated in women with PBC and PSC. However, they recommend counselling women concerning the increased risk of preterm birth. Identification of women at risk of preterm delivery could be possible done via measuring maternal alanine transferase (ALT) and bile acids. They observed negative correlation of gestation at birth with maternal serum ALT concentration at booking and serum bile acid concentration during pregnancy.