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Pregnancy in women with psoriatic arthritis: A systematic literature review of disease activity and adverse pregnancy outcomes

Seminars in Arthritis and Rheumatism Apr 19, 2021

Meissner Y, Rudi T, Fischer-Betz R, et al. - This study was intended to examine available data on (I) disease activity during pregnancy and on (II) adverse pregnancy outcomes (APO) in women with psoriatic arthritis (PsA). Researchers further evaluated neonatal outcomes and treatment of the rheumatic disease. They carried out to search systematic literature search within the databases Pubmed and Embase until 30 Nov 2020. Via two reviewers, the English language was systematically assessed. For this analysis, the review of 734 search results revealed 13 eligible publications reporting on a total of 2,332 pregnancies in women with PsA. The data exhibited a postpartum deterioration of disease activity in women with PsA and no risk elevation for gestational diabetes, small for gestational age, and low birth weight. In PsA pregnancies, a higher risk for pre-eclampsia, elective caesarean section, and preterm birth cannot be ruled out. In women with PsA, variations in the studies investigated limit overall summary statements on disease activity and APOs. The outcomes demonstrated that harmonization of study approaches, instruments, and outcome reporting is crucial to ensure informed counselling of patients with PsA before, during, and after pregnancy that is based on robust data.

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