Kinuthia J, Pintye J, Abuna F, et al. - In view of an increased risk of HIV acquisition among pregnant women in settings with high HIV prevalence and subsequent vertical transmission, researchers implemented and assessed a novel program to render preexposure prophylaxis (PrEP) in maternal and child health clinics in Kenya. PrEP delivery was integrated within 16 maternal and child health clinics in Kisumu County (Kenya) in collaboration with the Kisumu County Department of Health. Between Nov 20, 2017, and June 13, an assessment of 9,376 pregnant and postpartum women for behavioral risk factors and willingness to receive PrEP. PrEP initiation was done in 2,030 (21·7%), overall. Of these, 2027 had the status of their partner captured (153 [79·3%] of 193 women with partners living with HIV, 1178 [37·2%] of 3165 women with partners of unknown HIV status, and 696 [11·6%] of 5997 women with HIV-negative partners). The multivariate analysis revealed following factors as predictors of PrEP initiation: being younger than 24 years; having a partner living with HIV (6·96, 5·46–8·89) or of unknown HIV status (3·08, 2·50–3·81); gestational age of less than 26 weeks (1·22, 1·02–1·47); having been diagnosed or treated for a sexually transmitted infection (1·57, 1·20–2·06); having been forced to have sex (1·82, 1·38–2·42); having experienced intimate partner violence during the previous 6 months (1·65, 1·10–2·48); having shared needles while engaging in injection drug use (2·43, 1·69–3·50); and recurrent use of postexposure prophylaxis (1·96, 1·36–2·82). Overall, 786 (38·7%) of 2,030 women who initiated PrEP continued use after the first month, with 104 (68·0%) of 153 women who had a partner living with HIV continuing use. In the multivariable model, the only predictor of PrEP continuation at 1 month was having a partner living with HIV. Side effects and low HIV risk perception were the frequent reasons for discontinuation. Women on PrEP had no incident HIV infection.