Liu FT, et al. - In 45 Parkinson's disease (PD) patients with bilateral subthalamic deep brain stimulation (STN DBS) surgery and followed up for 1 year, researchers identified the related factors and possible predictors to quality of life (QoL) improvement. The Reliable Change Index (RCI) has been adapted to determine the individual postoperative QoL results. According to the findings, 51.1% of the patients reported a better QoL, 40.0% of patients reported an unchanged QoL, while 8.9% of patients reported a deterioration in QoL. After surgery, the subdomains of mobility, daily life activity, cognition, and bodily discomfort improved significantly. Pre-operative factors such as QoL, dopaminergic medication burden, disease stages, depression scores, and postsurgical reductions in depression and nonmotor scores have been found to correlate with QoL changes. In addition, the higher presurgical QoL burden, lesser dopaminergic medication exposure, and earlier disease stages were predictors of QoL improvements. Investigators suggested that physicians should carefully assess the nonmotor symptoms and quality of life in patients at relatively earlier stages and with a lower dosage of medicine to achieve more successful DBS results.