Rajamaki TJ, Puolakka PA, Hietaharju A, et al. - This research was sought to distinguish risk factors for the increased use of opioids and other analgesics 1 year after surgery and targeted on comorbidities and surgery-related factors. Between 2002 and 2013, researchers distinguished all individuals who had undergone a primary hip or knee replacement for osteoarthritis. This study included 6,238 hip replacement and 7,501 knee replacement recipients. They obtained redeemed prescriptions for acetaminophen, non-steroidal anti-inflammatory drugs, and opioids (mild and strong) from a nationwide Drug Prescription Register. They further estimated user rates of analgesics and the adjusted risks ratios for analgesic use 1 year after joint replacement. The results of this study exhibit that obesity (particularly BMI > 35 kg/m2) and the preoperative usage of analgesics were the strongest prognosticators of an elevated postoperative use of analgesics. It is notable that also older age and higher number of comorbidities prognosticated analgesic usage despite these individuals being the most vulnerable to adverse drug events.