Rodriguez M, Thille AW, Boissier F, et al. - In this retrospective monocenter observational study run for 2 years, researchers evaluated the factors that can predict successful separation from high-flow nasal oxygen therapy (HFOT) in critically ill patients, excluding those who died or were intubated without previous HFOT separation effort, who were managed with non-invasive ventilation at the time of HFOT separation, or who received HFOT as a preventive treatment during the post-extubation period. They analyzed 190 patients in total. Successful separation from HFOT at the first attempt was reported in 168 (88%). Longer ICU length of stay was noted in those who failed separation from HFOT at the first trial vs those who succeeded. Displaying a respective sensitivity of 85% and 84%, the fraction of inspired oxygen (FiO₂) ≤ 40% and a respiratory rate-oxygenation index (calculated as the ratio of oxygen saturation/FiO₂ to the respiratory rate) ≥ 9.2 were identified as 2 predictors of successful separation from HFOT at the bedside.