Orr SL, et al. - Researchers performed a retrospective study of all migraine patients seen at the Cincinnati Children’s Hospital Headache Center from September 1, 2006 to December 31, 2017 who was followed up at least once within 1-3 months of the index visit to describe the short-term prognosis of a clinical population of pediatric and young adult patients with migraine. In addition, they sought predictive factors of clinical worsening while in care. They defined clinical worsening as an increase in 4 or more headache days per month between the index visit and the follow-up. Analyzing data for 13,160 visit pairs (index and follow-up), from 5,316 patients, they noted the majority of pediatric patients improved over time with multimodal interdisciplinary care for migraine. Clinical worsening was noted in only 14.5% (1,908/13,160), whereas 56.8% of visit intervals (7,475/13,160) showed reduced headache frequency, with 34.8% of the intervals (4,580/13,160) showing 50% or greater reduction. Significantly higher odds of worsening were noted with increasing age, female sex, chronic migraine, status migrainosus, depressive symptoms, higher PedMIDAS scores, and use of nutraceuticals; lower odds of worsening were noted for summer visits, caffeine drinkers, higher headache frequencies, and use of pharmaceuticals.