Yadav K, et al. - In this study, for the first time, researchers sought for predictors associated with oral antibiotic treatment failure for nonpurulent skin and soft tissue infections (SSTIs) in the Emergency Department via performing health records review of adults (age ≥ 18 years) with nonpurulent SSTIs treated at two tertiary care Emergency Departments (EDs). As per findings, oral antibiotic treatment failure was evident in independent association with tachypnea at triage, chronic ulcers, history of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection, and cellulitis within the past year. They recommend addressing these risk factors when deciding on oral vs intravenous antimicrobial therapy for outpatient management of nonpurulent SSTIs.