Kim D, et al. - In non-obese and obese nonalcoholic fatty liver disease, researchers compared demographic and clinical characteristics and determinants of nonalcoholic steatohepatitis and significant fibrosis. Study participants were 664 Asian subjects (mean age 53.1 years; men 50.3%) with biopsy-proven nonalcoholic fatty liver disease and controls. The results from the cross-sectional study indicate that non-obese subjects with nonalcoholic fatty liver disease demonstrated a comparable severity of histological liver damage as obese subjects. Findings suggested that factor(s) beyond obesity might play a role as non-obese nonalcoholic fatty liver disease advances to more severe disease. Female sex, higher alanine aminotransferase, lower high-density lipoprotein cholesterol, higher prevalence of diabetes, and higher visceral adipose tissue area were predictors of nonalcoholic steatohepatitis in nonobese subjects. On the other hand, age, higher aspartate aminotransferase, diabetes, and higher visceral adipose tissue area were related to significant fibrosis in the non-obese.