Bian W, Wan J, Tan M, et al. - Using a longitudinal study design, researchers sought to investigate descriptive trends in health-related quality of life (HRQoL) and their predictive factors in Chinese age-related macular degeneration (AMD) patients receiving treatment with vascular endothelial growth factor inhibitors (anti-VEGF) at baseline and follow-ups. In a study of 142 AMD patients with a mean age of 63.49 (SD = 11.07) years from the Southwest Eye Hospital's outpatient clinic, a tertiary major hospital in the southwest of China, each patient completed a self-administered questionnaire evaluating demographics, clinical characteristics, HRQoL, depression, anxiety, coping style, social support, and self-efficacy at baseline and at 1-, 3-, 6-, and 12-month follow-up appointments. According to multivariable linear regression, the predictors of HRQoL are best-corrected visual acuity (BCVA), income level, depression, and visual acuity (VA) of the treated eye at baseline; BCVA, income, and depression at the 1-month follow-up; duration, area of residence, gender, VA of the treated eye, BCVA, income, anxiety, social support, self-efficacy, and depression at the 3-month follow-up; gender, BCVA, income, anxiety, social support, self-efficacy, depression, negative coping, and positive coping at the 6-month follow-up; and BCVA, social support, self-efficacy, and depression at the 12-month follow-up. In Chinese AMD patients receiving anti-VEGF treatment, the HRQoL and its predictive factors fluctuated over time. It is proposed that medical staff should obtain more knowledge when preparing a specific treatment to enhance the HRQoL of patients.