Predictors of fatal outcomes among hospitalized COVID-19 patients with pre-existing hypertension in China
The Clinical Respiratory Journal Jun 01, 2021
Wang T, Tang R, Ruan H, et al. - Researchers investigated the factors that decide the clinical course as well as results of coronavirus disease 2019 (COVID-19) patients with hypertension. This study involved 148 COVID-19 cases with preexisting hypertension, of which 103 were discharged and 45 died in hospital. High-sensitivity cardiac troponin (hs-cTn) > 28 pg/ml and interleukin-6 (IL-6) > 7 pg/ml at admission were identified to be related to higher odds of in-hospital death, as revealed on multivariate regression. The probability of having ICU admission, invasive mechanical ventilation, and renal injury was more in patients with uncontrolled blood pressure (BP). Lower mortality was reported in relation to a stricter BP control with the threshold of 130/80 mm Hg. Findings revealed that patients with fatal outcomes could be identified at an early stage with the help of elevated hs-cTn and IL-6 in this study population of COVID-19 cases with pre-existing hypertension. Better clinical outcomes resulted from blood pressure control, and no increment in mortality was seen in relation to renin-angiotensin-aldosterone system suppressors use; rather these agents may reduce the necessity for ICU admission.
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