Rossello X, et al. - In EPICOR trial—a prospective, international, real-world cohort study that included consecutive patients hospitalized for acute coronary syndrome (ACS) within 24 hours of symptom onset and surviving to discharge—researchers investigated whether there exists a difference in risk predictors for all-cause mortality and ischemic events between year 1 and 2 of follow-up post-ACS. Participants included 10,568 patients (555 hospitals; 20 countries) followed-up for 2 years. Among these participants, 4,943 were admitted with ST-elevation myocardial infarction (STEMI) and 5,625 with non-ST-elevation ACS (NSTE-ACS). In year 1 and 2 post-discharge, potential baseline predictors of major adverse cardiac and cerebrovascular events (MACCE; death, non-fatal myocardial infarction [MI], non-fatal stroke) were assessed. Post-discharge follow-up of 2 years revealed continuous MACCE risk, with greater mortality reported within the first year. Risk factors for MACCE in both year 1 and 2 included older age, lack of coronary revascularization, raised creatinine, low hemoglobin, previous cardiac disease, previous chronic obstructive pulmonary disease, raised glucose, male sex, and geographic region. After 1 year, low ejection fraction, poorer quality of life, low BMI < 20 kg/m², in-hospital cardiac complications, and Killip class failed to predict MACCE. Specific predictors at discharge for events after 1 year could not be identified.