Spirito A, Nestor B, Massing-Schaffer M, et al. - Researchers aimed at determining the predictors and moderators of substance use outcomes among 111 adolescents with co-occurring substance use and psychiatric disorders who participated in a randomized controlled trial that compared the effectiveness of two home-based treatments: an integrated cognitive behavioral therapy (I-CBT) protocol, in which masters-level clinic staff received intensive training and ongoing supervision in the use of this protocol vs a treatment-as-usual (TAU) comparison condition in which therapists received a continuing education–style CBT workshop in the same protocol. Low parental monitoring at baseline, as assessed by a videotaped interaction task, but not self-report, was identified as predictive of adolescent marijuana and heavy alcohol use days over a 6-month follow-up period; this was noted regardless of treatment condition. Over a 6-month follow-up period, adolescents in the CBT condition showed significantly more reduction in their percentage of heavy alcohol use days if their parents entered treatment with low levels of parental monitoring compared with adolescents in treatment-as-usual. Irrespective of treatment condition, greater marijuana use days were observed over a 6-month follow-up period in correlation with greater adolescent aggression and parental emotion dysregulation at baseline. Significantly more reduced heavy alcohol use days were recorded in adolescents in the CBT condition who reported low positive urgency at baseline relative to adolescents in treatment-as-usual over the 6-month follow-up period.