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Predictive value of positive temporal artery biopsies in patients with clinically suspected giant cell arteritis considering temporal artery ultrasound findings

Graefe's Archive for Clinical and Experimental Ophthalmology Aug 22, 2019

Sommer F, et al. - In patients with clinically suspected giant cell arteritis (GCA), researchers studied the effect of ocular symptom, non-ocular symptom, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and temporal artery ultrasound (TAU) findings on the predictive value of a positive temporal artery biopsy (TAB). Data from 68 patients with clinically suspected GCA who had TAB between 2015 and 2017 were analysed in a retrospective, interventional study. Five parameters were included in the analysis: ocular symptom, non-ocular symptom, ESR, CRP level and TAU findings. A positive TAB was not significantly linked to the presence of ocular symptoms. The combined parameters TAU, ESR and CRP were able to predict a positive TAB in 97.3% of all patients using discriminant analysis. Data reported that the positive predictive value was 78.3% and the negative predictive value was 95.4%. In patients who show an elevated ESR and CRP level and a positive TAU, temporal artery biopsy to confirm the diagnosis of GCA may not be compulsory.
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