Liu, X Wang L, Zhou K, et al. - This research was sought to prospectively evaluate the value of C-reactive protein-to-albumin (CAR) in predicting both initial and repeated intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD), and to test the hypothesis that CAR was more valuable or accurate than either C-reactive protein (CRP) or albumin (ALB) alone in IVIG resistance prediction. Researchers performed a prospective cohort study including a total of 550 patients with KD. They applied receiver operating characteristic (ROC) curves analysis to evaluate the validity of CAR, CRP, and ALB in predicting both initial and repeated IVIG resistance. The findings revealed that for both initial and repeated IVIG resistance, a higher CAR was an independent risk factor. Nevertheless, the outcomes suggested that similar to that of CRP or ALB, the predictive value of CAR was not good enough for both initial and repeated IVIG resistance prediction in KD.