Omarini C, Palumbo P, Pecchi A, et al. - In this retrospective review, researchers analyzed patients treated for operable breast cancer (BC), to determine the links between body composition parameters (BCPs) and tumor response to neoadjuvant chemotherapy (NC) in these patients. The participants were recruited from Modena Cancer Center. They used Advance workstation (General Electric), software ADW server 3.2 or 4.7 to calculate BCPs, such as subcutaneous fat area, visceral fat area (VFA), lumbar skeletal muscle index and liver-to-spleen ratio. They examined 407 cases: 55% with BMI < 25 and 45% with BMI ≥ 25. A significant link of overweight with postmenopausal status and older age was identified. Overweight patients more often developed hormonal receptor positive BC. Higher VFA, fatty liver disease and obesity were seen in postmenopausal women vs premenopausal patients. Negative predictive factors for pathological complete response were high VFA and liver steatosis. Overall survival and relapse-free survival were not significantly affected by either BMI classes or BCPs. Findings revealed close involvement of visceral adiposity and steatosis in chemosensitivity in BC patients managed with NC. Significant predictive information that outperformed BMI value was obtained from the measures of visceral adiposity and steatosis from clinically acquired computed tomography scans.