Moulla Y, et al. - In this retrospective analysis of non-small cell lung cancer (NSCLC) patients who had oncological surgical resections from January 2007 to December 2016 from a prospectively-established database, researchers assessed the predictive factors for lymph node metastasis. They used univariate and binary logistic regression analysis to assess the correlation between clinicopathological parameters and lymph node metastasis. A total of 204 consecutive patients were operated on, 142 men (71.7%) and 56 women (28.3%), with 38.2% (78/204) having lymph node metastases. Preoperatively, factors that significantly predicted lymph node metastasis included central tumor localization and tumor size > 3 cm. Postoperatively, factors that showed significant correlation with lymph node metastasis in multivariate analysis included intratumoral lymph vessel invasion (L1-status) and central tumor localization. Central tumor localization and L1-status were identified as two predictive factors for lymph node metastasis in small size tumors (≤3 cm). L1-status was identified as a very significant risk factor for lymph node metastasis. An adjuvant therapy was recommended in patients with L1-status and pNX category.