da Silva Boteon APC, et al. - Via performing a retrospective analysis of patients admitted in acute-on-chronic liver failure (ACLF) to a tertiary intensive care unit between 2013 and 2017, researchers identified predictive factors for short-term mortality in patients admitted with ACLF that may benefit most from liver transplantation. Multivariable analysis, including severity-of-disease scores and clinical parameters, was carried out using 28-day mortality as an endpoint. Throughout the study period, 77 patients were admitted to ACLF. Data reported that the most common liver disease aetiology was alcohol-related 52/77 (68%) and variceal haemorrhage 38/77 (49%) was the most common precipitant of ACLF. Findings revealed that patients admitted to intensive care with ACLF have a high rate of mortality. Defined early admission thresholds can identify patients at the highest risk that may most benefit from liver transplantation.