Rehbinder EM, Endre KMA, Carlsen KCL, et al. - A total of 1,150 mother-child pairs were included from the Preventing Atopic Dermatitis (AD) and Allergies in children prospective birth cohort study in order to recognize parental, prenatal and perinatal predictive factors of dry skin, high TEWL and AD at 3 months of age, and to ascertain whether dry skin or high transepidermal water loss (TEWL) at 3 months could prognosticate AD at 6 months. For dry skin at 3 months were delivery > 38 gestational weeks and paternal age > 37 years, for high TEWL; male gender, birth during the winter season and maternal allergic disease, and for eczema; elective cesarean section, multiparity, and maternal allergic diseases were important predictive factors. Dry skin without eczema at 3 months was auspicious for eczema at 6 months, whereas high TEWL at 3 months was not. Hence, in early infancy, for dry skin, high TEWL, and AD, different parental and pregnancy-related factors were predictive in nature. Moreover, at 3 months of age, dry skin was imminent for AD three months later.