Nomura O, et al. - Febrile young infants are at high risk for severe infection. While measuring vital sign parameters in these patients may serve as a rapid and effective evaluation, researchers investigated their predictive value for serious bacterial infection (SBI). Study participants included febrile (>38.0°C) infants aged <90 days at the time of presentation. Variables involved patient age, gender, and vital sign data, including body temperature, pulse rate, oxygen saturation, definitive diagnosis, and disposition. On logistic regression, a significant predictor of SBI was body temperature of ≥38.5°C. In this retrospective observational study involving 269 patients (mean age of 55 days), high-grade fever in febrile young infants was found to be an important predictor of SBI.