van der Hoeven A, van der Beek MT, Lopriore E, et al. - Considering the relevance of early prediction of the absence of a culture-proven sepsis (CPS) as it would significantly decrease the time of antibiotic treatment and hospitalization, researchers sought to analyze 3 criteria in infants with CPS: positive blood culture (BC) at 24 hours after the onset of suspicion of EOS (OSEOS), C-reactive protein (CRP) ≥ 10 mg/L and clinical signs of infection. Among all infants with suspicion of early onset sepsis (EOS), they calculated the proportion of (1) infants with CPS with, at 24 hours, a positive BC and/or CRP ≥ 10 mg/L and/or clinical signs of infection and (2) infants without CPS with CRP < 10 mg/L between 12 and 24 hours after OSEOS. Per findings, 98% (49/50) of infants who develop CPS 24 hours after OSEOS can be predicted by assessing the combination of BC, CRP, and clinical signs of infection. In 74% of infants, the decision to stop antibiotics could have been brought forward to 24 hours based on normal CRP and the absence of a positive BC.