Wei Y, Xu Q, Yang H, et al. - In this study, researchers examined whether preconception blood fasting plasma glucose (FPG) level influences subsequent pregnancy outcomes. In this population-based retrospective cohort study of 6,447,339 women (aged 20–49 years old), who participated in National Free PrePregnancy Checkups Project and completed pregnancy outcomes follow-up between 2010 and 2016 in China, they observed diabetes mellitus (DM) incidence of 1.18% (76,297) and impaired fasting glucose [IFG] incidence of 13.15% (847,737). Observations revealed a higher risk of adverse pregnancy outcomes, including spontaneous abortion, preterm birth (PTB), macrosomia, small for gestational age infant (SGA), and perinatal infant death, among women with preconception IFG or DM. Women with IFG vs those with normal FPG had higher risks of spontaneous abortion (OR 1.08; 95% CI 1.06–1.09), PTB (1.02; 1.01–1.03), macrosomia (1.07; 1.06–1.08), SGA (1.06; 1.02–1.10), and perinatal infant death (1.08; 1.03–1.12). For women with DM, the corresponding ORs were 1.11 (95% CI 1.07–1.15), 1.17 (1.14–1.20), 1.13 (1.09–1.16), 1.17 (1.04–1.32), and 1.59 (1.44–1.76), respectively. Findings support preconception glycemic control through appropriate methods as one of the most important aspects of preconception care that should not be overlooked by policymakers.