Toida T, et al. - In this cohort study, researchers assessed mortality in relation to pre- and postdialysis uric acid (UA) difference (UAD) in 1,073 patients receiving maintenance hemodialysis (HD). Participants were followed up for 5 years. Based on baseline UAD, quartile categories of patients were formed. The link between UAD categories and all-cause and cardiovascular (CV) mortalities was examined while adjusting for potential confounders in Cox’s regression analyses. In the analysis for all-cause mortality, the lowest UAD group (< 4.7 mg/dL) had significantly higher hazard ratios vs the highest UAD group (> 6.2 mg/dL). Findings revealed no correlation with CV mortality. For controlling UA in HD patients, the most appropriate reference may be UAD.