Sauer BC, Chen W, Shen J, et al. - This study was carried out to assess the effect of major therapeutic change (MTC) on clinical response across a broad range of disease activity in US veterans with rheumatoid arthritis (RA). Researchers conducted a historical cohort analysis to evaluate patient visits from the Veterans Affairs RA registry between January 1, 2006 and September 30, 2017. The study population consisted of 1,208 patients (6,138 visits) and the active disease subpopulation included 383 patients (1,109 visits). It was shown that MTC was correlated with clinical improvement, even among patients with longstanding RA who had received multiple prior therapies, which emphasizes the utility of therapy modifications for patients with established and active RA.