Xie L, et al. - In this investigation, researchers identified potential biomarkers for primary open-angle glaucoma (POAG) diagnosis. By microarray analyses, lncRNA and message RNA (mRNA) expression profiles in the aqueous humor (AH) from 10 POAG and 10 control patients were accessed. In addition, lncRNAs-T267384, ENST00000607393, and T342877 expression were further tested by quantitative real-time PCR in AH from 29 POAG and 30 cataract patients, in iris tissues from 16 POAG patients and 10 controls, and in plasma from 49 POAG patients and 55 healthy controls. Seven lncRNAs exhibited positive correlation with glaucoma associated gene, bone morphogenetic protein 2. In addition, RT-qPCR confirmed that the expression of T267384, ENST00000607393 and T342877 from a different cohort of POAG patients was significantly higher in the AH. Data reported that lncRNA-T267384, ENST00000607393, and T342877 might be potential biomarkers for POAG diagnosis. Overall, findings suggested that ENST00000607393 might be a new therapeutic target for trabecular meshwork calcification.