Terock J, Hannemann A, Van der Auwera S, et al. - Researchers examined the link between posttraumatic stress disorder (PTSD) and vitamin D levels in a general population sample of the Study of Health in Pomerania (SHIP-1). Furthermore, they explored the role of the vitamin D-binding protein (also group-specific component or Gc) by testing the association of two functional polymorphisms (rs4588 and rs7041) with vitamin D levels and PTSD. The analysis revealed an inverse relation of 25(OH)D levels and a positive association of vitamin D deficiency with PTSD. They noted an association of both polymorphisms of the Gc with 25(OH)D levels and PTSD: Carriers of the CC-genotype of rs4588 exhibited significantly higher 25(OH)D levels and lower odds for PTSD relative to the AA-genotype. Likewise, lower 25(OH)D levels and increased odds for PTSD were observed among carriers of the TT-allele of rs7041 relative to the GG-genotype. Results thereby suggest an involvement of an altered vitamin D metabolism in the pathophysiology of PTSD.