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Postprandial triglycerides predict newborn fat more strongly than glucose in women with obesity in early pregnancy

Obesity Jun 28, 2018

Barbour LA, et al. - Researchers tested the premise that fasting triglycerides (TGs) and postprandial triglycerides (PPTGs) were higher in women with obesity (OB) compared with women with normal weight (NW) throughout pregnancy, correlate more strongly with newborn percent fat (NB%fat) than glucose, and might relate to dietary chylomicron TGs. For this analysis, fasting TGs and PPTGs, free fatty acids, glucose, and insulin were prospectively measured 10 times over 4 hours after a controlled liquid breakfast early (14-16 weeks) and later (26-28 weeks) in pregnancy in 27 mothers with NW and 27 with OB. They discovered that 1- or 2-hour PPTGs could be a new target for early intervention in pregnancies with OB to prevent excess newborn adiposity and attenuate child OB risk.
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