Jung KY, et al. - From 1982 to 2012, researchers conducted a retrospective analysis to assess secular trends in clinicopathological features and long-term prognosis of medullary thyroid carcinoma (MTC) and its predictive factors. For this investigation, they included 331 patients with MTC and grouped based on the year of diagnosis (1982–2000, 2001–2005, 2006–2010 and 2011–2012). Findings revealed that mean tumor size and percentage of extrathyroidal extension decreased. They observed that the percentage of patients achieving biochemical remission (BCR) within 6 postoperative months (po-BCR) increased with time. In 2006–2012, the overall 5-year recurrence rate decreased significantly compared to 1982–2005, although the 5-year survival rate did not improve. Overall, they concluded that clinicopathological features and recurrence of MTC got better over time. For recurrence-free survival, po-BCR was the best predictive factor. Significant prognostic factors for mortality were male gender, tumor size >2 cm and distant metastasis.