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Posterior reversible encephalopathy syndrome in children: A prospective follow-up study

Journal of Child Neurology Oct 05, 2019

Darwish AH - Using Wechsler Intelligence Scale, electroencephalograph (EEG), and brain MRI, the researcher assessed the clinical and radiologic presentation and neurologic outcome of pediatric posterior reversible encephalopathy syndrome (PRES). The study sample consisted of 24 children [mean age was 6 years (± 2.2)] diagnosed with PRES who were prospectively followed for 2 years. The main disorders associated with PRES in children were neoplastic, renal disorders, and hematopoietic stem cell transplantation. The main risk factors for pediatric PRES were chemotherapeutic drugs, immunosuppressants, and hypertension. Pediatric PRES results are good, but there may be long-term neurological sequelae, mostly epilepsy and residual MRI abnormalities. PRES recurrence in children receiving chemotherapy or immunosuppressive drugs is rarely reported. Recurrent PRES is a long-term neurological sequelae risk factor.
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