De Martin H, et al. - In this study, researchers develop a novel one-step intracytoplasmic sperm injection (ICSI) approach to select sperm with better chromatin maturity than the conventional method. The current study shows that the positive rheotaxis extended drop (PRED) method may improve the current ICSI technique by providing it with its own sperm selection process. ICSI would probably become an even more complete technique comprising selection, capture and injection of the male gamete.