Rimmler C, Lanckohr C, Mittrup M, et al. - Researchers conducted the study for exploring pharmacokinetic and pharmacodynamic aspects of a contemporary dosing scheme of cefuroxime as perioperative prophylaxis in cardiac surgery using cardiopulmonary bypass. Cefuroxime plasma concentrations have been measured in 23 patients. Target unbound concentrations of 32 mg/L can be obtained during surgery with a bolus dose of 1 g accompanied by a continuous infusion of 1 g/h of cefuroxime. Recommendations for the dosage of cefuroxime as perioperative antibiotic prophylaxis in cardiac surgery are adequate to achieve unbound plasma concentration during surgery to cover the S. aureus. In the postoperative period, target attainment is not achieved. Continuous cefuroxime infusion can maximize target achievement.