• Profile
Close

Population pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis during and after cardiopulmonary bypass

British Journal of Clinical Pharmacology Nov 26, 2020

Rimmler C, Lanckohr C, Mittrup M, et al. - Researchers conducted the study for exploring pharmacokinetic and pharmacodynamic aspects of a contemporary dosing scheme of cefuroxime as perioperative prophylaxis in cardiac surgery using cardiopulmonary bypass. Cefuroxime plasma concentrations have been measured in 23 patients. Target unbound concentrations of 32 mg/L can be obtained during surgery with a bolus dose of 1 g accompanied by a continuous infusion of 1 g/h of cefuroxime. Recommendations for the dosage of cefuroxime as perioperative antibiotic prophylaxis in cardiac surgery are adequate to achieve unbound plasma concentration during surgery to cover the S. aureus. In the postoperative period, target attainment is not achieved. Continuous cefuroxime infusion can maximize target achievement.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay