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Population improvement bias observed in estimates of the impact of antenatal steroids to outcomes in preterm birth

The Journal of Pediatrics Jan 06, 2021

Gould JB, Bennett MV, Phibbs CS, et al. - Experts aspired to explore whether increasing rates and differential uptake of antenatal steroids would bias estimation of the impact of antenatal steroids on neonatal death and severe (grade III-IV) intraventricular hemorrhage (IVH). The sample consisted of infants (n = 28,252) born between 24 and 28 weeks of gestational age in the California Perinatal Quality Care Collaborative. Antenatal steroid exposure rose from 80.1% in 2005 to 90.3% in 2016, severe IVH declined from 14.5% to 9.0%, and mortality dropped from 12.8% to 9.1%. As the proportion of antenatal steroid usage in the population grew, the beneficial effects of antenatal steroids also increased. This apparent increase may be referred to as a "population improvement bias."

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